P-216 Incidence and trends of biliary tract cancer in Girona: A population-based study from the Girona Cancer Registry (1994-2016)

We identified 1,102 BTC incident adult cases (>15y), 49.5% females and 50.5% males. Median age at diagnosis was 75y (R25-101). According to histology, 66% of cases were epithelial tumors, 1% neuroendocrine neoplasms, and 2 non-epithelial tumors were detected (1 Lymphoma, 1 sarcoma). The remaining 33% of cases had non-specified histology (“Neoplasm, malignant”). The most frequent subsite was ECC (26.2%), followed by GB (23.2%) and ICC (22.7). We found 143(12.9%) cases arising from AV, 3 overlapping tumors, and 160 cases (14.5%) were classified as biliary tract, NOS. Analysis: For the selected study population (N=1,088; non-epithelial and neuroendocrine tumors excluded) crude rate (CR) cancer incidence was 7.32 cases per 100,000 inhabitants/year (7.43 men; 7.21 women). Regarding the ASR, results show an ASRE13 of 8.39 (95% CI 7.9; 8.9) and ASRW of 3.26(95% CI 3.0; 3.5). A slight non-statistically significant decrease in the incidence of BTC cases over the study period was observed, with an EAPC of -0.18 (95% CI -1.09-; 0.73) per year. We analyzed trends in the incidence of epithelial BTC histologically confirmed (n=722) and BTC with non-specified histology (n=366) separately, finding an opposite behavior in each group: an increase of confirmed cases overtime (up to a 28% total increase at the end of the study period) and a concurrent decrease in the number of non-specified histology cases.